Loved the work of Ramirez et al. They have tried to erase memory from the mice.
If you have time please do read their nature paper (*Liu X., *Ramirez, S., Pang, P., Puryear, C., Govindarajan, A., Deisseroth, K., and Tonegawa S.Optogenetic stimulation of a hippocampal engram activates fear memory recall. Nature (2012), doi:10.1038/nature11028.)
The feeling of publishing a paper has two key components: the unforgiving roller coaster leading up to publication — a process that feels like an airplane is perpetually parked on the face of your self-esteem — and the part after the paper has been accepted — a process that feels like a double-thick oreo milkshake multiplied by world peace. Both processes are bound together by research. Research is what happens when you navigate onto the edge of what is known and unknown. Neuroscientists are cartographers of the brain, and this story is about how my first two years as a grad student in Susumu Tonegawa’s lab (T-lab) have been an adrenal gland-squeezing voyage to understand how uncharted neural waters make the wine of memory possible. I took the hippocampic oath; we called the voyage Project X.
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